Pharmaceutical Microbiology (Principles & Applications) by Prof. Chandrakant KokareBook Summary:Continued demands for this book and rapid progress in pharmaceutical microbiology have encouraged me to produce this new edition. This edition has been prepared by valuable suggestions of students and teachers from the pharmacy and science field. Nearly all chapters are revised and updated by considering rapid changes and progress being made in certain areas.
Microbiology is a basic science dealing with the study of micro-organisms. Pharmaceutical microbiology is related to microbial aspects of production and testing of drugs, cosmetics and medical devices. Detailed knowledge on microbiological methods is necessary for production and analysis of different pharmaceuticals and other products. Biotechnology is also an advanced field of microbiology.
Interestingly, sixteen of the most abundant GH families in the culture-independent dataset were found to be the predominant in the culture-dependent approach, and all the GH families with higher abundances in the labeled SIP samples were also observed in the culture-dependent dataset. Furthermore, the MAGs also contained GH families of interest, with variable abundances among them. MAG1 (similar to Paraburkholderia) contained 8 ORFs belonging to family GH92, which encompasses alpha-mannosidases with applications in food and pharmaceutical industries, for the production of juices, degradation of plant material, or coffee extraction . In MAG2 (similar to Amantichitinum), five ORFs were classified as GH23, which contains lysozymes that can be used as polysaccharide hydrolysers for biofilm breakdown [2, 50]. MAG3 (Rhodanobacteraceae) is abundant in GH92 and GH23 but also GH2 family ORFs, which comprises several enzymes. Within the best characterized ones, there are β-galactosidases employed for the production of lactose-free milk products and other galactooligosaccharides . MAG4 (similar to Amantichitinum) is rich in GH18 enzymes, involving chitinases that for instance are important agents with applications for fungal biological control and bioremediation processes . It is important to recognize that, even though the MAGs possessed a low level of contamination (< 5%), they do not represent genomes of axenic cultures from isolated microorganisms. Therefore, the corresponding laboratory cultures should still be recovered in order to fully validate our MAGs. 1e1e36bf2d